CKD one of the non-communicable diseases was forecasted to be raised in the cases, in which there is rise in uraemic toxins which may leads to secondary complication, hence we intended to study the inflammation due to uraemic toxicity. The study subjects were picked randomly. The basic information, the patient history was collected and blood samples were drawn after obtaining a written consent form. The patients were grouped into four different groups as, Group I (controls) contain normal healthy individuals free from all the systemic ailments (n=50). Group II contains individuals with CKD stage 1 &2 (n=50) Group III contains individuals with CKD stage 3, 4 & 5 (n=50). Group IV contains individuals with Hemodialysis (n=50). The study protocol was approved by the Institutional Ethics Committee. Biochemical parameters like fasting blood glucose, RFT, uric acid and inflammatory biomarkers were analyzed. Although inflammation may have protective, but in hemodialysis the inflammation does persist which can lead to development of CV events. In this regard we suggest to estimate the CRP levels along with YKL-40 to decide the doses of dialysis to reduce the inflammation as a conceptive therapy to reduce the CV events.