Welcome to IJMPR (Online ISSN-2958-3683 ; Print ISSN-2958-3675)
Best Indexing
Userfull Links
Why us?
Recently Published Papers
This study aimed to compare the clinical effects of hyperbaric ropivacaine alone and in combination with dexmedetomidine for spinal anesthesia in elective lower limb orthopedic procedures. A prospective, randomized, double-blind study was conducted on 100 patients undergoing elective lower limb orthopedic surgeries. Patients were randomly allocated into two groups: Group R received hyperbaric ropivacaine 0.75% (3 mL)+0.5 ml normal saline(total volume 3.5ml), and Group RD received hyperbaric ropivacaine 0.75% (3 mL) with dexmedetomidine (10μg) (total volume 3.5ml). The onset and duration of sensory and motor block, hemodynamic parameters, time to first analgesic request, and side effects were recorded. Results showed that the addition of dexmedetomidine to hyperbaric ropivacaine significantly prolonged the duration of sensory and motor block (p < 0.001), extended the time to first analgesic request (p < 0.001), and provided better intraoperative conditions compared to ropivacaine alone. Hemodynamic parameters remained stable in both groups, with no significant differences in side effects. This study concludes that the addition of dexmedetomidine to hyperbaric ropivacaine for spinal anesthesia in lower limb orthopedic procedures provides superior analgesia and prolonged motor and sensory block without significant hemodynamic alterations or increased side effects.
Dr.Varun Pradeepnath, Dr.Shivakumar, K. P
DOI : 10.5281/zenodo.14211008
This study aimed to compare the clinical effects of hyperbaric ropivacaine alone and in combination with dexmedetomidine for spinal anesthesia in elective lower limb orthopedic procedures. A prospective, randomized, double-blind study was conducted on 100 patients undergoing elective lower limb orthopedic surgeries. Patients were randomly allocated into two groups: Group R received hyperbaric ropivacaine 0.75% (3 mL)+0.5 ml normal saline(total volume 3.5ml), and Group RD received hyperbaric ropivacaine 0.75% (3 mL) with dexmedetomidine (10μg) (total volume 3.5ml). The onset and duration of sensory and motor block, hemodynamic parameters, time to first analgesic request, and side effects were recorded. Results showed that the addition of dexmedetomidine to hyperbaric ropivacaine significantly prolonged the duration of sensory and motor block (p < 0.001), extended the time to first analgesic request (p < 0.001), and provided better intraoperative conditions compared to ropivacaine alone. Hemodynamic parameters remained stable in both groups, with no significant differences in side effects. This study concludes that the addition of dexmedetomidine to hyperbaric ropivacaine for spinal anesthesia in lower limb orthopedic procedures provides superior analgesia and prolonged motor and sensory block without significant hemodynamic alterations or increased side effects.
Background: Acute pancreatitis is a disease with high rate of morbidity and mortality and is known to run an unpredictable course. Computed tomography is the gold standard technique not only for its global picture of the pathology and for the non-invasive method of evaluating the morphology of pancreas and peripancreatic regions in an acute situation. The purpose of the study was to determine the value of computed tomography evaluation in early diagnosis of severity, differences between pancreatitis & acute pancreatitis caused by mass lesions. Methodology: A prospective study comprise of 60 patients on clinical suspicion/diagnosis of acute pancreatitis, altered biochemical parameters (serum amylase, serum lipase) in favor of acute pancreatitis, Ultrasonography suggestive of acute pancreatitis and known case of chronic pancreatitis with features of acute symptoms referred to Department ofRadiology & Imaging, BSMMU, Dhaka, Bangladesh from January to June 2024. Plain and post-contrast series of the abdomen and pelvis were taken. Results: Outof 60 patients, 45 were male and 15 were female patients. Among these edematous pancreatitis was in 20% patients and pancreatic necrosis was in 23.3% patients. Other features like diffuse/focal pancreatic enlargement in (75%), peri-pancreatic fat stranding in (63.3%) and peri-pancreatic fluid collection in (40%). Among this alcohol was the most common cause of AP (83.3%). The accuracy and sensitivity of serum amylase and serum lipase in diagnosing AP were 40% and 63.3% respectively with CT showing 100% accuracy and sensitivity. Modified CT severity index was classified as mild (2 and 4), moderate (6) and severe (8 and 10) of which majority were mild (66%), moderate (22%) and severe (12%). Conclusion: Computed tomography is a sensitive, non-invasive imaging in early diagnosis and staging of severity of acute pancreatitis which help in prediction of prognosis of the disease. It helps to differentiate between edematous and necrotizing pancreatitis as serum lipase and amylase levels do not help to differentiate the type of AP. Modified CT severity index helps in evaluating the percentage pancreatic necrosis and to predict the possibility of developing local and systemic complications and necessity of tertiary care.
Mohammad Ali Kabir , Md. Nazrul Islam Mollah , Mahmud Hassan Mostafa Kamal , ASM Shahidul Hossain , Zereen Sultana , Sayeda Nazlee Mustafa , Md. Helal Uddin Bhuiyan
DOI : 10.5281/zenodo.14799621
Background: Acute pancreatitis is a disease with high rate of morbidity and mortality and is known to run an unpredictable course. Computed tomography is the gold standard technique not only for its global picture of the pathology and for the non-invasive method of evaluating the morphology of pancreas and peripancreatic regions in an acute situation. The purpose of the study was to determine the value of computed tomography evaluation in early diagnosis of severity, differences between pancreatitis & acute pancreatitis caused by mass lesions. Methodology: A prospective study comprise of 60 patients on clinical suspicion/diagnosis of acute pancreatitis, altered biochemical parameters (serum amylase, serum lipase) in favor of acute pancreatitis, Ultrasonography suggestive of acute pancreatitis and known case of chronic pancreatitis with features of acute symptoms referred to Department ofRadiology & Imaging, BSMMU, Dhaka, Bangladesh from January to June 2024. Plain and post-contrast series of the abdomen and pelvis were taken. Results: Outof 60 patients, 45 were male and 15 were female patients. Among these edematous pancreatitis was in 20% patients and pancreatic necrosis was in 23.3% patients. Other features like diffuse/focal pancreatic enlargement in (75%), peri-pancreatic fat stranding in (63.3%) and peri-pancreatic fluid collection in (40%). Among this alcohol was the most common cause of AP (83.3%). The accuracy and sensitivity of serum amylase and serum lipase in diagnosing AP were 40% and 63.3% respectively with CT showing 100% accuracy and sensitivity. Modified CT severity index was classified as mild (2 and 4), moderate (6) and severe (8 and 10) of which majority were mild (66%), moderate (22%) and severe (12%). Conclusion: Computed tomography is a sensitive, non-invasive imaging in early diagnosis and staging of severity of acute pancreatitis which help in prediction of prognosis of the disease. It helps to differentiate between edematous and necrotizing pancreatitis as serum lipase and amylase levels do not help to differentiate the type of AP. Modified CT severity index helps in evaluating the percentage pancreatic necrosis and to predict the possibility of developing local and systemic complications and necessity of tertiary care.
Background: Lymphomas are malignant clonal neoplasms of lymphocytes and their precursor forms. They are mainly of two types – non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Incidence of lymphomas, especially NHL is increasing worldwide and also in India, therefore morbidity due to the disease is also increasing. Thus, knowledge of its pathogenesis, histomorphology and immunophenotype will lead to possible early diagnosis and treatment of this potentially curable disease. In this background, a study has been conducted. Objective: 1) To study the histomorphological features of malignant nodallymphomas. 2) To evaluate the expression of a panel of immunohistochemical markers for categorisation of nodal malignant lymphomas and theirsubtypes. Methods:A study was conducted for a period of 6 and a half years from January 2012 to June 2018 at the Department of Pathology, ESIC Medical College and PGIMSR with a sample size of 75 cases. All the cases diagnosed as nodal lymphomas during that period, were included in the study. Immunohistochemistry (IHC) was performed. Data was compiled onto a masterchart and descriptive statistics performed. Results: Majority patients presented with cervical lymphadenopathy. NHL was morecommon than HL among nodal lymphomas. Among NHL, diffuse large B cell lymphoma was the most common.AmongHL,nodularsclerosiswasthemostcommonsubtype.BothHLandNHLhad a male predominance. The mean age in HL was lower than that inNHL. Interpretation and Conclusion: Clinicopathological correlation and a goodhistomorphological diagnosis,supplementedbyimmunohistochemistrywillenableefficientdiagnosisofmaligna nt nodal lymphomas, and enable application of targeted therapyoptions
A Histomorphological and Immunohistochemical Study of Malignant Nodal Lymphomas
Burji Rutuja, A, B. R. Vani, V. Srinivas Murthy
DOI : 10.5281/zenodo.12781492
Background: Lymphomas are malignant clonal neoplasms of lymphocytes and their precursor forms. They are mainly of two types – non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Incidence of lymphomas, especially NHL is increasing worldwide and also in India, therefore morbidity due to the disease is also increasing. Thus, knowledge of its pathogenesis, histomorphology and immunophenotype will lead to possible early diagnosis and treatment of this potentially curable disease. In this background, a study has been conducted. Objective: 1) To study the histomorphological features of malignant nodallymphomas. 2) To evaluate the expression of a panel of immunohistochemical markers for categorisation of nodal malignant lymphomas and theirsubtypes. Methods:A study was conducted for a period of 6 and a half years from January 2012 to June 2018 at the Department of Pathology, ESIC Medical College and PGIMSR with a sample size of 75 cases. All the cases diagnosed as nodal lymphomas during that period, were included in the study. Immunohistochemistry (IHC) was performed. Data was compiled onto a masterchart and descriptive statistics performed. Results: Majority patients presented with cervical lymphadenopathy. NHL was morecommon than HL among nodal lymphomas. Among NHL, diffuse large B cell lymphoma was the most common.AmongHL,nodularsclerosiswasthemostcommonsubtype.BothHLandNHLhad a male predominance. The mean age in HL was lower than that inNHL. Interpretation and Conclusion: Clinicopathological correlation and a goodhistomorphological diagnosis,supplementedbyimmunohistochemistrywillenableefficientdiagnosisofmaligna nt nodal lymphomas, and enable application of targeted therapyoptions
Cancer of the oral cavity is one of the most common malignancy worldwide. The oral cavity cancer is a major public health problem in the Indian subcontinent, where it ranks among the top three cancer types in both incidence and mortality. The substantial risk factor includes tobacco products, alcohol, poor oral hygiene, nutrition, viral and dentition. There is high prevalence of oral cancer in western Odisha due to rampant use of tobacco. Oral cancer generally refers to squamous cell carcinoma of oral mucosal origin, which accounts for more than 90 percent of all malignancies. Early detection is easy and associated with improvement in survival whereas late detection results in significant morbidity and mortality. Well differentiated carcinomas have minimal pleomorphism and few mitosis. Surgery and radiotherapy being the main modality of treatment. In our study the focus is to determine risk factors associated with oral cancer, to determine the commonest site of presentation, to find out the gender and age group with highest incidence, to find the presenting stage at the time of hospital visit.
Dr.Souvagini Acharya , Dr. Sabyasachi Pati , Dr. Richa Khetan , Dr. Subodh Kumar Bhoi, Dr. Rashmita Nayak
DOI : 10.5281/zenodo.14211968
Cancer of the oral cavity is one of the most common malignancy worldwide. The oral cavity cancer is a major public health problem in the Indian subcontinent, where it ranks among the top three cancer types in both incidence and mortality. The substantial risk factor includes tobacco products, alcohol, poor oral hygiene, nutrition, viral and dentition. There is high prevalence of oral cancer in western Odisha due to rampant use of tobacco. Oral cancer generally refers to squamous cell carcinoma of oral mucosal origin, which accounts for more than 90 percent of all malignancies. Early detection is easy and associated with improvement in survival whereas late detection results in significant morbidity and mortality. Well differentiated carcinomas have minimal pleomorphism and few mitosis. Surgery and radiotherapy being the main modality of treatment. In our study the focus is to determine risk factors associated with oral cancer, to determine the commonest site of presentation, to find out the gender and age group with highest incidence, to find the presenting stage at the time of hospital visit.
Background: Endothelial dysfunction serves as an early indicator of atherosclerosis, preceding structural changes. Its assessment offers insight into the preclinical phase of cardiovascular disease, particularly crucial in Type 2 Diabetes Mellitus (T2DM) due to its association with glycemic control and disease duration. Flow-mediated dilation (FMD), reliant on endothelial nitric oxide release in response to shear stress, reliably gauges endothelial function across various conditions. Aim of the Study: This study aimed to evaluate endothelial dysfunction in T2DM patients compared to age- and sex-matched healthy controls. Additionally, it sought to correlate the duration of diabetes with the prevalence of endothelial dysfunction and examine its association with atherosclerosis risk factors in T2DM. Methodology: Non-invasive assessment using high-resolution Duplex Doppler Ultrasound of the Brachial Artery was conducted on 50 T2DM cases with or without vascular complications and 20 healthy controls. FMD, calculated as percentage increase in brachial artery diameter with increased flow, was employed to quantify endothelial function. Results: Endothelial dysfunction was observed in 20% of diabetics but absent in controls. Mean FMD values were significantly lower in diabetics (8.38 ± 12.32%) compared to controls (17.12 ± 10.53%; p < 0.007). FMD decline was noted across diabetes durations (10 years: 3.50 ± 1.61%), though prevalence did not escalate with longer duration. Conclusion: T2DM patients exhibit significantly impaired endothelial function compared to healthy counterparts, as evidenced by reduced FMD. The prevalence of endothelial dysfunction did not correlate with diabetes duration but was associated with hypertension, family history of diabetes, and smoking. Early intervention targeting these risk factors and optimizing glycemic control may mitigate vascular complications in T2DM.
Endothelial dysfunction in type 2 diabetes mellitus compared to healthy subjects
Dr Dnyanesh N Morkar , Dr V Channaarya , Dr Anil Kumar Sharma , Dr Hima Morkar , Dr Saad Siddiqui
DOI : 10.5281/zenodo.13371592
Background: Endothelial dysfunction serves as an early indicator of atherosclerosis, preceding structural changes. Its assessment offers insight into the preclinical phase of cardiovascular disease, particularly crucial in Type 2 Diabetes Mellitus (T2DM) due to its association with glycemic control and disease duration. Flow-mediated dilation (FMD), reliant on endothelial nitric oxide release in response to shear stress, reliably gauges endothelial function across various conditions. Aim of the Study: This study aimed to evaluate endothelial dysfunction in T2DM patients compared to age- and sex-matched healthy controls. Additionally, it sought to correlate the duration of diabetes with the prevalence of endothelial dysfunction and examine its association with atherosclerosis risk factors in T2DM. Methodology: Non-invasive assessment using high-resolution Duplex Doppler Ultrasound of the Brachial Artery was conducted on 50 T2DM cases with or without vascular complications and 20 healthy controls. FMD, calculated as percentage increase in brachial artery diameter with increased flow, was employed to quantify endothelial function. Results: Endothelial dysfunction was observed in 20% of diabetics but absent in controls. Mean FMD values were significantly lower in diabetics (8.38 ± 12.32%) compared to controls (17.12 ± 10.53%; p < 0.007). FMD decline was noted across diabetes durations (10 years: 3.50 ± 1.61%), though prevalence did not escalate with longer duration. Conclusion: T2DM patients exhibit significantly impaired endothelial function compared to healthy counterparts, as evidenced by reduced FMD. The prevalence of endothelial dysfunction did not correlate with diabetes duration but was associated with hypertension, family history of diabetes, and smoking. Early intervention targeting these risk factors and optimizing glycemic control may mitigate vascular complications in T2DM.
Introduction: The imperative to address the high mortality rates associated with coronavirus disease (COVID-19) prompted a swift development of vaccines. By 2021, multiple vaccines had been introduced. However, a lack of conclusive long-term evidence regarding their effectiveness, coupled with apprehensions about potential effects on pregnancy, contributed to a diverse public reaction.Aim: To assess the perception of pregnant and postpartum/ postnatal women with respect to the COVID19 vaccine.Materials and Methods: A cross-sectional study was conducted among antenatal and postnatal mothers at a tertiary healthcare center, with data collection initiated only upon securing consent from study participants. The study, determining a sample size of 373, administered a 33-item questionnaire to the selected participants. Subsequently, the collected data underwent analysis utilizing SPSS software version 24.0.Results: The majority of participants in the study fell within the 28-32 age group (41.9%). When evaluating participant concern levels, 34.6% expressed moderate concern, with a notable association among those with college-level education. Notably, individuals testing positive for COVID-19 and those with COVID-19-positive family members displayed reduced likelihood of vaccine hesitancy. Concerns regarding the safety of COVID-19 vaccines emerged as a significant predictor of vaccine hesitancy. Moreover, participants exhibiting an enhanced sense of safety post-vaccination demonstrated a positive correlation with vaccine acceptance. Conclusion: COVID-19 vaccination acceptance remains suboptimal, with variations observed across demographic variables such as age, location, income, and occupation. Utilizing news and social media platforms can serve as effective tools to
Covid-19 Vaccine Receptivity Among Antenatal and Postnatal Women
Saju Denishya Prabhakaran , Richu Ravikumar , Dr. Poornima, C, Dr. Maheswari, S , Dr. S. Latha Maheswari
DOI : 10.5281/zenodo.13325891
Introduction: The imperative to address the high mortality rates associated with coronavirus disease (COVID-19) prompted a swift development of vaccines. By 2021, multiple vaccines had been introduced. However, a lack of conclusive long-term evidence regarding their effectiveness, coupled with apprehensions about potential effects on pregnancy, contributed to a diverse public reaction.Aim: To assess the perception of pregnant and postpartum/ postnatal women with respect to the COVID19 vaccine.Materials and Methods: A cross-sectional study was conducted among antenatal and postnatal mothers at a tertiary healthcare center, with data collection initiated only upon securing consent from study participants. The study, determining a sample size of 373, administered a 33-item questionnaire to the selected participants. Subsequently, the collected data underwent analysis utilizing SPSS software version 24.0.Results: The majority of participants in the study fell within the 28-32 age group (41.9%). When evaluating participant concern levels, 34.6% expressed moderate concern, with a notable association among those with college-level education. Notably, individuals testing positive for COVID-19 and those with COVID-19-positive family members displayed reduced likelihood of vaccine hesitancy. Concerns regarding the safety of COVID-19 vaccines emerged as a significant predictor of vaccine hesitancy. Moreover, participants exhibiting an enhanced sense of safety post-vaccination demonstrated a positive correlation with vaccine acceptance. Conclusion: COVID-19 vaccination acceptance remains suboptimal, with variations observed across demographic variables such as age, location, income, and occupation. Utilizing news and social media platforms can serve as effective tools to
Introduction: Diabetic retinopathy, most common complication of diabetes mellitus, isa microvascular disorder and ranks as the fourth major cause of blindness globally. According to the Early Treatment Diabetic Retinopathy Study (ETDRS)and Diabetic Retinopathy Study (DRS) timely intervention can reduce vision loss. Nursing and Pharmacy students serve as the resource persons for diabetic patients seeking information regarding diabetes and diabetic retinopathy. Hence, this study aimed to assess the knowledge, attitude and practices regarding diabetic retinopathy among nursing and pharmacy students in tertiary care teaching hospital. Objectives:To evaluate knowledge, attitude and practice regarding diabetic retinopathy among Nursing and Pharmacy students in tertiary care teaching hospital and to compare awareness between Nursing and Pharmacy students. Methods: This cross-sectional study was conducted among 360 Nursing and Pharmacy students by convenience sampling in a tertiary care teaching centre in Puducherry, India, from August 2023 to January 2024. Data was collected by administering the semi-structured questionnaire after taking consent and entered in Excel sheet and analysis was done using SPSS software version 23.0 Results: About 63.9% of the participants were found to be males and 36.1% were females. 52.8% were nursing students and 47.2% were pharmacy students. 62.5% of the participants had good knowledge about diabetic retinopathy and 60% had a positive attitude towards the disease. However, good practices were found in only 52.2% of the study participants. On comparison, nursing students had better knowledge, attitude and practice regarding diabetic retinopathy than pharmacy students Conclusion: According to our research, nursing and pharmacy students demonstrated a satisfactory knowlegde and positive attitude towards diabetic retinopathy. However, there is room for improvement in terms of practice level which will contribute to the early detection and treatment of diabetic retinopathy, ultimately reducing the risk of vision-threatening complications.
Dr. Chandhini, Dr. Loganathan, Dr. Nandini H lulla
DOI : 10.5281/zenodo.13378973
Introduction: Diabetic retinopathy, most common complication of diabetes mellitus, isa microvascular disorder and ranks as the fourth major cause of blindness globally. According to the Early Treatment Diabetic Retinopathy Study (ETDRS)and Diabetic Retinopathy Study (DRS) timely intervention can reduce vision loss. Nursing and Pharmacy students serve as the resource persons for diabetic patients seeking information regarding diabetes and diabetic retinopathy. Hence, this study aimed to assess the knowledge, attitude and practices regarding diabetic retinopathy among nursing and pharmacy students in tertiary care teaching hospital. Objectives:To evaluate knowledge, attitude and practice regarding diabetic retinopathy among Nursing and Pharmacy students in tertiary care teaching hospital and to compare awareness between Nursing and Pharmacy students. Methods: This cross-sectional study was conducted among 360 Nursing and Pharmacy students by convenience sampling in a tertiary care teaching centre in Puducherry, India, from August 2023 to January 2024. Data was collected by administering the semi-structured questionnaire after taking consent and entered in Excel sheet and analysis was done using SPSS software version 23.0 Results: About 63.9% of the participants were found to be males and 36.1% were females. 52.8% were nursing students and 47.2% were pharmacy students. 62.5% of the participants had good knowledge about diabetic retinopathy and 60% had a positive attitude towards the disease. However, good practices were found in only 52.2% of the study participants. On comparison, nursing students had better knowledge, attitude and practice regarding diabetic retinopathy than pharmacy students Conclusion: According to our research, nursing and pharmacy students demonstrated a satisfactory knowlegde and positive attitude towards diabetic retinopathy. However, there is room for improvement in terms of practice level which will contribute to the early detection and treatment of diabetic retinopathy, ultimately reducing the risk of vision-threatening complications.
Background:Seroma development, also referred to as "pseudorecurrence," is a frequent postoperative issue following TAPP treatment of inguinal hernias, menace to operating surgeon answering questions to patients either be a self-limiting, asymptomatic event or a painful, long-term issue. In order to better understand incident of postoperative seroma following laparoscopic transabdominal preperitoneal hernia repair (TAPP), which involves fixing transversalis fascia to Cooper ligament, a research investigation has been done.Methods:For direct inguinal hernias, TAPP was incorporated from October 2022 - December 2023. After cavity created by direct reduction of hernia had been closed in each patient by transversalis fascia fixation to coopers, a lightweight mesh was inserted. Data from clinical as well as demographic studies have been obtained as well as examined.Results: A total of 72 individuals that had TAPP repair during study period. Mean age of patients, who were all male, was 65.1 ± 10.7 yrs. Average hospital stay lasted between two and four days. Neither seroma nor recurrence was discovered 30 days after discharge, nor was chronic pain after 3–12 months mean follow-up.Conclusions: To avoid postoperative seromas, it is safe, practical, and advised to anchor transversalis fascia to Cooper ligament while treating a direct inguinal hernia with TAPP
Dr. Harsha Dileep, Prof. Dr.Affin Abdul Salim
DOI : 10.5281/zenodo.14211697
Background:Seroma development, also referred to as "pseudorecurrence," is a frequent postoperative issue following TAPP treatment of inguinal hernias, menace to operating surgeon answering questions to patients either be a self-limiting, asymptomatic event or a painful, long-term issue. In order to better understand incident of postoperative seroma following laparoscopic transabdominal preperitoneal hernia repair (TAPP), which involves fixing transversalis fascia to Cooper ligament, a research investigation has been done.Methods:For direct inguinal hernias, TAPP was incorporated from October 2022 - December 2023. After cavity created by direct reduction of hernia had been closed in each patient by transversalis fascia fixation to coopers, a lightweight mesh was inserted. Data from clinical as well as demographic studies have been obtained as well as examined.Results: A total of 72 individuals that had TAPP repair during study period. Mean age of patients, who were all male, was 65.1 ± 10.7 yrs. Average hospital stay lasted between two and four days. Neither seroma nor recurrence was discovered 30 days after discharge, nor was chronic pain after 3–12 months mean follow-up.Conclusions: To avoid postoperative seromas, it is safe, practical, and advised to anchor transversalis fascia to Cooper ligament while treating a direct inguinal hernia with TAPP
Gallbladder adenomyomatosis (GA) is a benign, proliferative condition characterized by gallbladder wall thickening and the presence of Rokitansky-Aschoff sinuses. Though generally asymptomatic, GA can mimic acute cholecystitis, leading to diagnostic challenges. We present a case of a 32-year-old male with a year-long history of recurrent right hypochondriac pain radiating to the shoulder, accompanied by nausea and vomiting. Initial clinical and laboratory findings suggested acute cholecystitis. Imaging studies, including ultrasonography and magnetic resonance cholangiopancreatography, revealed diffuse gallbladder wall thickening with cystic spaces, indicative of adenomyomatosis. The absence of gallstones and the presence of a dilated cystic duct further supported the diagnosis. The patient underwent elective laparoscopic cholecystectomy, and histopathological examination confirmed diffuse adenomyomatosis with smooth muscle hypertrophy and Rokitansky-Aschoff sinuses. The postoperative recovery was uneventful, and the patient remained asymptomatic during a six-month follow-up. Gallbladder adenomyomatosis is benign and can be detected by imaging or during cholecystectomy. Theoretically, adenomyomatosis doesn't need any special care unless it presents symptoms, whether or not cholecystolithiasis is present.
Gallbladder Adenomyomatosis Mimicking Acute Cholecystitis in Young Male
Dr. E. Abdul Salim , Prof. Dr, Affin Abdul Salim, Dr. Harsha Dileep
DOI : 10.5281/zenodo.13585468
Gallbladder adenomyomatosis (GA) is a benign, proliferative condition characterized by gallbladder wall thickening and the presence of Rokitansky-Aschoff sinuses. Though generally asymptomatic, GA can mimic acute cholecystitis, leading to diagnostic challenges. We present a case of a 32-year-old male with a year-long history of recurrent right hypochondriac pain radiating to the shoulder, accompanied by nausea and vomiting. Initial clinical and laboratory findings suggested acute cholecystitis. Imaging studies, including ultrasonography and magnetic resonance cholangiopancreatography, revealed diffuse gallbladder wall thickening with cystic spaces, indicative of adenomyomatosis. The absence of gallstones and the presence of a dilated cystic duct further supported the diagnosis. The patient underwent elective laparoscopic cholecystectomy, and histopathological examination confirmed diffuse adenomyomatosis with smooth muscle hypertrophy and Rokitansky-Aschoff sinuses. The postoperative recovery was uneventful, and the patient remained asymptomatic during a six-month follow-up. Gallbladder adenomyomatosis is benign and can be detected by imaging or during cholecystectomy. Theoretically, adenomyomatosis doesn't need any special care unless it presents symptoms, whether or not cholecystolithiasis is present.
Introduction: Stroke is defined as rapidly developing symptoms and/or signs of focal and global loss of cerebral function lasting for at least 24 hours with no apparent cause other than of vascular origin. It constitutes a dreadful burden of disability. Modifiable risk factors include hypertension, diabetes and hypercholesterolemia, atrial fibrillation, smoking, drug abuse, and alcohol intake. Changes in the lipid profile have been suggested with formation of atherosclerosis. Aims and objective: To evaluate lipid profile levels in patient with acute ischemic stroke and to compare this parameter with severity of stroke. Materials and methods: The cross-sectional study of one and half year duration (Feb2021-Aug2022) was done on 100 patients of acute ischemic stroke presented to K.R. Hospital, Mysore. The main goal was to determine whether hypercholesterolemia is a risk factor for high severity.Lipid profile was measured by collecting the patients’ blood after fasting for 9 to 12 hours. Severity of stroke was assessed by NIHSS. Based on NIHSS scores divided into minor (1-4), moderate (5-15), moderate to severe (16- 20), severe (21-42) groups. Along with assessment with severity, lipid profile was compared between severity of stroke. Statistical analysis: Data analysed using SPSS software version 22.0 and it will be presented as descriptive statistics in form of frequency table and graphs. Association between variables will be done using chi-square test and unpaired t test for qualitative and quantitative variables. Result will be expressed as mean+/-SD. Correlation of parameters is done by Pearson’s correlation formula. A p value of <0.05 is considered statistically significant. Results and conclusion: Among 100 cases higher levels of TC, TGL, LDL were associated with more severity of stroke. 9 were in minor group, 47 were in moderate group, 29 were in moderate to severe group, 15 were in severe group. As the severity increases the mean level of TC, TGL, LDL, VLDL also increases, mean HDL level decreases. P value being <0.05, statistically Significant, showing clinical correlation with severity of stroke. Higher TC, TGL, LDL and lower HDL increases the risk of severity of stroke. Association Were strong for higher level of TC and LDL Early detection and treating with lipid lowering drugs helps to reduce the risk and prevent morbidity and mortality.
ROLE OF LIPID PROFILE IN ACUTE ISCHEMIC STROKE
Dr. Kavya. D , Dr. Vignesh, Dr. Basavaraju. M. M
DOI : 10.5281/zenodo.13373891
Introduction: Stroke is defined as rapidly developing symptoms and/or signs of focal and global loss of cerebral function lasting for at least 24 hours with no apparent cause other than of vascular origin. It constitutes a dreadful burden of disability. Modifiable risk factors include hypertension, diabetes and hypercholesterolemia, atrial fibrillation, smoking, drug abuse, and alcohol intake. Changes in the lipid profile have been suggested with formation of atherosclerosis. Aims and objective: To evaluate lipid profile levels in patient with acute ischemic stroke and to compare this parameter with severity of stroke. Materials and methods: The cross-sectional study of one and half year duration (Feb2021-Aug2022) was done on 100 patients of acute ischemic stroke presented to K.R. Hospital, Mysore. The main goal was to determine whether hypercholesterolemia is a risk factor for high severity.Lipid profile was measured by collecting the patients’ blood after fasting for 9 to 12 hours. Severity of stroke was assessed by NIHSS. Based on NIHSS scores divided into minor (1-4), moderate (5-15), moderate to severe (16- 20), severe (21-42) groups. Along with assessment with severity, lipid profile was compared between severity of stroke. Statistical analysis: Data analysed using SPSS software version 22.0 and it will be presented as descriptive statistics in form of frequency table and graphs. Association between variables will be done using chi-square test and unpaired t test for qualitative and quantitative variables. Result will be expressed as mean+/-SD. Correlation of parameters is done by Pearson’s correlation formula. A p value of <0.05 is considered statistically significant. Results and conclusion: Among 100 cases higher levels of TC, TGL, LDL were associated with more severity of stroke. 9 were in minor group, 47 were in moderate group, 29 were in moderate to severe group, 15 were in severe group. As the severity increases the mean level of TC, TGL, LDL, VLDL also increases, mean HDL level decreases. P value being <0.05, statistically Significant, showing clinical correlation with severity of stroke. Higher TC, TGL, LDL and lower HDL increases the risk of severity of stroke. Association Were strong for higher level of TC and LDL Early detection and treating with lipid lowering drugs helps to reduce the risk and prevent morbidity and mortality.
Follow Us
About Us
IJMPR is an international open access source for a high quality and peer reviewed journal in the fields of Medical and Pharmaceutical Sciences. IJMPR publishes research papers across all academic disciplines in the fields of Medical, Pharmaceutical Sciences.