International Journal of Medical and Pharmaceutical Research
2025, Volume-6, Issue-1 doi: 10.5281/zenodo.12781166
Original Research Article
Use of chloroprocaine in spinal anaesthesia - A comparative study of combination of chloroprocaine with fentanyl vs. chloroprocaine with nalbuphine for day care surgeries
Published
Feb. 26, 2025
Abstract

Background: The subarachnoid block is a preferred regional modality for patients undergoing surgeries of below umbilical region. In this perspective, we aimed to compare the efficacy and safety of 40 mg intrathecal chloroprocaine1% alone versus in combination with nalbuphine 0.8mg and fentanyl 20 mcg as an adjuvant in day care surgeries performed under subarachnoid block. Method: Overall, 150 patients were enrolled in this research. They were randomly divided into three groups of 50 each with the help of computer-generated random tables. Both the patient and the observer were blinded to the study. Group C, NC and FC received 40mg of 1% chloroprocaine (4ml) with 1 ml normal saline, nalbuphine 0.8 mg in 1 ml, fentanyl 20μg in 1 ml intrathecally respectively. Result: The time of onset of sensory block was calculated when sensory block was achieved at the level L1. No significant difference was observed between groups in onset of sensory block, peak sensory block level and time to reach peak sensory block level. The time for two-segment regression and regression to S2 was statistically significant between groups as the mean time was fastest in group C followed by group FC and NC. The VAS score was greater in control group as compared to group FC and NC at 120 minutes. Conclusion: Thus, we conclude that addition of opioids as an adjuvant to intrathecal short acting local anaesthetic 1% chloroprocaine have synergistic effect on analgesic action without affecting motor block.

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