CKD one of the non-communicable diseases was forecasted to be raised in the cases, in which there is rise in uremic toxins which may leads to secondary complication, hence we intended to study the endothelial dysfunction due to uremic toxicity. The study subjects were picked randomly. The basic information, the patient history was collected and blood samples were drawn after obtaining a written consent form. The patients were grouped into four different groups as, Group I (controls) contain normal healthy individuals free from all the systemic ailments (n=50). Group II contains individuals with CKD stage 1 &2 (n=50) Group III contains individuals with CKD stage 3, 4 & 5 (n=50). Group IV contains individuals with Hemodialysis (n=50). The study protocol was approved by the Institutional Ethics Committee. Biochemical parameters like fasting blood glucose, RFT, uric acid and endothelial dysfunction markers were analysed. Multiple risk factors of CVD may influence the rise of ADMA and E-selectin. Our study confined to only CKD individuals has noted increased ADMA and E-selectin is due to the endothelial dysfunction which may influence CKD in development of vascular injury causes increase in mortality rate in these individuals by developing the CVD.