Introduction: Urinary bladder cancer is a prevailing cancer of the urinary system. Worldwide it is the ninth most common type of cancer. There are broadly two histological types of bladder cancers: urothelial and non- urothelial. Urothelial carcinoma is the predominant type with an incidence of 90-95%. Non-urothelial cancers are further subdivided into epithelial and nonepithelial. Epithelial cancers include squamous cell carcinoma, adenocarcinoma,andsmall cell tumors whereas nonepithelial cancers which are further more rare, include sarcomas, melanomas, lymphomas,and paragangliomas. Neurofibromas of thegenitourinary tract arise, from nerves of thepelvic, vesical and prostatic plexuses. Cystitis glandularis is also a very rare benign proliferative disease of urinary bladder mucosa and is usually a microscopic diagnosis and rarely manifests as a large visible macroscopic mass of urinary bladder. Materials and Methods: This is a prospective study conducted in a tertiary care hospital comprising six cases of unusual urinary bladder lesions. We studied the cases according to their age, sex, clinical presentation, location within the bladder, radiological findings, histopathological findings, immunohistochemical findings and treatment provided. Results: This study comprisessix cases of unusual primary urinary bladder lesions which includes one case of squamous cell carcinoma, mucinous adenocarcinoma, clear cell carcinoma, paraganglioma, neurofibroma cystitis glandularis each. The patients belong to a wide age range between 3rd to 7th decade. There is male predominance. Hematuria is the common clinical presentation in all of them. Different locations within the bladder is involved in all these six cases. Histopathological examination followed by immunohistochemical staining of the formalin fixed paraffin embedded tissue sections confirmed their diagnosis. Conclusion:There are several histological variants of urinary bladder cancers, however squamous cell carcinoma, mucinous adenocarcinoma, and clear cell carcinoma are extremely rare. Extensive work-up, including immunohistochemical studies are required to rule out both the possibility of other sites of these primary tumors and possibility of metastasis. Isolated urinary bladder neurofibromas are extremely rare which requires clinical follow up to monitor potential recurrence or progression. Paraganglioma are even more rare and incidentally detected. Cystitis glandularis is a chronic disease and should be considered as a distinct clinical entity.