In middle-aged females, abdominal pain or discomfort with dyspepsia is a very common complaint. The cause of abdominal pain can vary from hepatobiliary, genitourinary, intestinal, or even functional. Clinical history and examination findings help the clinician with potential diagnostic clues and further management. But even after comprehensive workup, sometimes diagnosis remains uncertain though the proportion of such patients in the above subset of patients is very few. Here in our case series, we diagnosed and treated such patients who had rare causes of pain abdomen- which included neuroendocrine tumors- gastric and duodenal, and mucinous cystic neoplasm of the pancreas.