Aims and objective-The present study was undertaken to evaluate the role of ultrasound guided fine needle aspiration cytology for the diagnosis and management of patients suffering from pyogenic liver abscess. Materials and methods- A total of 24 patients presenting with right upper abdominal pain, high grade fever, nausea, vomiting and loss of appetite were seen in surgical and medical opd were send for ultrasound guided F.N.A.C. in our department. Results- Out of 24 patients of pyogenic liver abscess (PLA), 18 patients (75%) were male and 6 patients (25%) were female. Age group was ranging from 15-65 years. Majority of patients 22 (91.66%) were presenting with upper abdominal pain followed by fever with rigor in 14(58.33%). About 13(54.16%) patients has unknown cause and must be due to cryptogenic in origin. The most common pathogens isolated were Klebsiella spp., Conclusion- Prompt ultrasound guided percutaneous fine needle needle aspiration and drainage of pus along with intravenous antimicrobial shows excellent recovery of patients from the disease.