The Effect of 96% Ethanol Extract of Moringa Leaf (Moringa oleifera) on Insulin Level in Wistar Rats Model(Rattus norvegicus) with PCOS (Polycystic Ovarian Syndrome)

doi:10.5281/zenodo.14636177

International Journal of Medical and Pharmaceutical Research

2025, Volume-6, Issue-1 doi: 10.5281/zenodo.14636177

Original Research Article

The Effect of 96% Ethanol Extract of Moringa Leaf (Moringa oleifera) on Insulin Level in Wistar Rats Model(Rattus norvegicus) with PCOS (Polycystic Ovarian Syndrome)

Dezaundra Ayesha Zachranie, Salmon Charles P. T. Siahaan, Hendera Henderi , Rahajoe Imam Santoso

DOI : 10.5281/zenodo.14636177

Published

Jan. 13, 2025

Abstract

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder which cause hyperandrogenism, anovulation, and also polycystic ovaries. The effect of PCOS can reach several organs such as cardiovascular, immune system, reproductive, metabolic, and psychological. This study investigates the effect of moringa leaves on insulin level within rats model with PCOS. Methods: Data were collected through Post Test Only Control Group Design with Wistar rats (Rattus norvegicus) model from the insulin level in the body. The rats are injected with testosterone and then given Moringa leaf extract. Results: The analysis revealed that the PCOS rats have an increased insulin levels than the normal rats and there isa significant decrease in insulin levels in rats given Moringa leaf extract with the PCOS rats. Normal rats and rats given Moringa leaf extract have almost the same Insulin level. Conclusions: These findings suggest that Moringa leaf extract decreased the insulin levels with PCOS rats. Further research needed to find more about the impact of Moringa leaf extract on rats insulin levels.

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