Background: Leukocytosis is well known to be a significant indicator of inflammatory response and have predictive value on the functional outcome in ischemic stroke.Numerous studies have analyzed the correlation between leukocyte count and the severity of ischemic stroke based on National Institutes of Health Stroke Scale (NIHSS). However, studies specifically focused on neutrophil count are still limited. The aim of this study is to explore the correlation between neutrophil count and ischemic stroke severity evaluated using NIHSS.Method: This analytical observational study used cross-sectional design and purposive sampling, with a total sample of 27 ischemic stroke patients. The neutrophil count and NIHSS scorewere collected at admission and then analyzed using Spearman correlation test. Results: This research found a significant relationship between neutrophil count and ischemic stroke severity based on NIHSS, with a p-value of <0.001. The correlation coefficient is 0.858, indicating a linear and very strong correlation.Conclusion: There was a significant correlation between neutrophil count and the severity of ischemic stroke based on NIHSS score