The clinical utility of local anaesthesia with adjuvant provides excellent nerve block with prolonged duration and faster action onset. There are various approaches for giving brachial plexus block among which supraclavicular plexus block is commonly used for upper limb surgeries. This study focuses on comparing the effects of dexmedetomidine and dexamethasone as adjuvants in ultrasound guided supraclavicular brachial plexus block. A total of 150 ASA (American society of anaesthesiologist) grade 1 and 2 patients aged 18-60 undergoing upper limb surgery were divided into two groups according to randomised double blind study - Group A given 20 mL of 0.5% Bupivacaine with 50 mcg (0.5ml) of dexmedetomidine and Group B given 20 mL of 0.5% Bupivacaine with dexamethasone 8mg (2ml). In both groups, 0.9% normal saline was added to make a total volume of 25 mL. Onset and duration of sensory and motor blocks, along with intraoperative analgesia quality were evaluated. The onset of sensory blocks was faster in patients in group A as compared to group B patients. In terms of duration of block, sensory and motor block and in terms of duration for post op analgesia were maintained for longer duration in Group A patient compared to group B patient.