Background: Surgical site infections (SSIs) are a common complication following elective laparoscopic cholecystectomy. Identifying the incidence and risk factors associated with SSIs is crucial for improving surgical outcomes. Objective: To determine the incidence of SSIs and identify the risk factors associated with infections in patients undergoing elective laparoscopic cholecystectomy. Methods: A prospective observational study was conducted with 50 patients who underwent elective laparoscopic cholecystectomy. Demographic data, surgical details, and postoperative outcomes were recorded. SSIs were classified into superficial, deep incisional, and organ/space infections. Risk factors such as diabetes, BMI, smoking, and operative time were analyzed using statistical methods. Results: The overall incidence of SSIs was 10%, with 5 patients developing infections: 3 superficial (6%), 1 deep incisional (2%), and 1 organ/space infection (2%). Diabetes was significantly associated with SSIs (30%, p = 0.02), as was obesity (BMI >30) with 25% of obese patients affected (p = 0.03). Prolonged operative time (>120 minutes) was another significant risk factor (33.3%, p = 0.01). Smoking showed a trend toward increased infection risk but was not statistically significant (25%, p = 0.08). Common pathogens included Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae. Two of the infections involved antibiotic-resistant organisms. Conclusion: The incidence of SSIs in elective laparoscopic cholecystectomy was 10%, with diabetes, obesity, and prolonged operative time being significant risk factors. Prophylactic antibiotic use was effective in reducing infection rates. Identifying high-risk patients can help tailor preventative strategies to reduce SSI incidence.