International Journal of Medical and Pharmaceutical Research
2023, Volume-4, Issue-3 doi: 10.5281/zenodo.7927846
Original Article
Study to Correlate the Pressure-to-Cornea Index (PCI) with Structural and Functional Measures of Glaucoma
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Published
May 12, 2023
Abstract
Introduction: Glaucoma is a multi factorial optic neuropathy that is a leading cause of irreversible blindness worldwide. Peripapillary choroidal thickness (PCT) is a significant parameter in the pathogenesis of glaucoma. In this study, we aimed to evaluate the normative database of PCT and its correlation with structural and functional measures of glaucoma. Methods: A cross-sectional study was conducted on 71 glaucoma patients. PCT was measured using spectral-domain optical coherence tomography. Structural measures including cup-to-disc (CD) ratio, central corneal thickness (CCT), and intraocular pressure (IOP) were recorded. The functional measure was the mean deviation (MD) of the visual field. Statistical analysis was performed using SPSS version 21. Results: The mean age of the patients was 56.2±9.4 years. PCT was not affected by gender. There was a weak positive correlation between PCT and age (r=0.256, p=0.011). PCT was significantly correlated with CCT (r=-0.301, p=0.003) and IOP (r=0.546, p<0.001). CD ratio did not show a significant correlation with PCT (r=0.033, p=0.770). Similarly, no significant correlation was found between PCT and MD (r=-0.160, p=0.139). Conclusion: PCT is a useful parameter in glaucoma evaluation, and our study provides a normative database for PCT in glaucoma patients. PCT showed a significant correlation with CCT and IOP. The integration of PCT with these parameters may better reflect an individual's susceptibility to glaucomatous damage than either parameter alone. However, PCT did not correlate with CD ratio or MD, suggesting that it may have limited use as a structural or functional measure of glaucoma. Further studies are needed to validate these findings and determine the clinical utility of PCT in glaucoma management.
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