Introduction: A spectrum of hematological manifestations are seen at every stage of human immunodeficiency virus (HIV) infection, and they often pose a great challenge in the Diagnosis and management.

Out of all complications, Hematological abnormalities, Anemia is the most common abnormality seen in HIV s patients and its incidence is strongly associated with the progression of the disease.

Objectives: The present study aims to study the hematological manifestation in newly detected HIV patients & to study the relationship between various haematological manifestation with WHO clinical staging.

Methodology: It is a observational and descriptive study done at ART CENTRE VIMS, BALLARI, with a sample size of 108 cases. Patients who filled the inclusion criteria are assessed as per proforma specially designed for study.

Conclusion: The study concluded that anaemia was the most common haematological abnormality followed by elevated ESR, thrombocytopenia, leucopenia. CD4 count is the best predictor of WHO staging.