Background: Deep vein thrombosis (DVT) is a common complication in patients undergoing abdominal surgery. This study aimed to identify the risk factors associated with the development of DVT in patients following abdominal surgery. Methods: A prospective observational study was conducted on 100 patients who underwent abdominal surgery between January 2022 and December 2022. Demographic data, comorbidities, surgery-related factors, and postoperative care measures were collected. Logistic regression analysis was performed to identify the risk factors associated with the development of DVT. Results: The incidence of DVT in this patient population was 4.9%. Logistic regression analysis revealed that patients who underwent major abdominal surgery for malignancy and those with surgery duration of ≥2 hours were at significantly higher risk of developing DVT post-surgery. Age, sex, BMI, and comorbidities such as hypertension, diabetes, and smoking were not significant risk factors. Prophylactic anticoagulants, mechanical compression devices, and early mobilization did not show a significant effect on the development of DVT. Conclusions: This study suggests that patients who undergo major abdominal surgery for malignancy and those with surgery duration of ≥2 hours are at higher risk of developing DVT post-surgery. Clinicians should be aware of these risk factors and take appropriate measures to prevent DVT in these high-risk patients. Future studies are needed to further evaluate the effectiveness of prophylactic measures in preventing DVT in post-surgical patients.