Background: The objective of this study was to determine the incidence of port site infections and associated risk factors among patients undergoing laparoscopic surgeries. Methods: A retrospective chart review was conducted on 285 patients who underwent laparoscopic surgeries in a tertiary care hospital from January 2022 to December 2022. Data on patient demographics, surgical characteristics, and incidence of port site infections and associated complications were collected. Statistical analysis was performed to determine the risk factors for port site infections and associated complications. Results: The majority of the patients were between 31-50 years old (44.2%), and cholecystectomy was the most common type of surgery (35.0%). Out of 285 patients, 20 (7%) developed port site infections, with hernia repair having the highest incidence (9%). Superficial incisional SSIs were the most common type of infection (3.5%). The odds ratios for age, gender, BMI, and underlying medical conditions were not statistically significant. However, the odds ratio for the duration of surgery was 1.19, indicating that longer surgery duration may increase the risk of port site infections and associated complications. Conclusion: The findings of this study suggest that the risk of developing port site infections varies depending on the type of laparoscopic surgery, with longer surgery duration possibly increasing the risk. While there were no statistically significant associations found between age, gender, BMI, and underlying medical conditions with the risk of port site infections and associated complications, patients with comorbidities may be at a higher risk. Further research is needed to identify additional risk factors and develop strategies to reduce the incidence of port site infections.