Study Of Changes In Coagulation Profile Of Patients Undergoing Laparoscopic Cholecystectomy Using Carbon Di Oxide Pneumoperitoneum

doi:10.5281/zenodo.16416937

International Journal of Medical and Pharmaceutical Research

2025, Volume-6, Issue-4 : 183-221 doi: 10.5281/zenodo.16416937

Original Article

Study Of Changes In Coagulation Profile Of Patients Undergoing Laparoscopic Cholecystectomy Using Carbon Di Oxide Pneumoperitoneum

Dr Hussain Ahmed

Dr Hosni Mobarok Choudhery

Dr Wasim Akram

DOI : 10.5281/zenodo.16416937

Published

July 17, 2025

Abstract

INTRODUCTION: Laparoscopic cholecystectomy has replaced open cholecystectomy and is now the gold standard procedure for gallbladder disease. Pneumoperitoneum plays a crucial role in the procedure and carbon dioxide is commonly chosen gas. This study aims to find the effects of carbon dioxide pneumoperitoneum on coagulation profile and assess if there is an increased risk of thrombosis.

MATERIALS AND METHOD: This prospective and observational study includes 50 patients undergoing Laparoscopic cholecystectomy under General Anaesthesia. Patient’s 3cc blood was drawn just before surgery and 6 hour after surgery to analyse PT and D-Dimer and then was compared.

RESULTS: In 34 patients Prothrombin Time decreased 6hour after surgery, while 1 patient experienced an increase and rest 15 patients maintained similar Prothrombin Time values. The mean difference between the two groups was 0.130, with a 95% confidence interval ranging from 0.031 to 0.229, the p-value was 0.0109. D-dimer values revealed an increase in all patients postoperatively. The mean D-dimer levels before and after surgery were 0.1834 mcg/ml and 0.3364 mcg/ml, respectively, with standard deviations of 0.0486 and 0.0395, respectively. During the 2weeks postoperative follow-up, none of the patients showed clinical signs of DVT.

CONCLUSION: The study reveals a notable increase in D-dimer levels and a significant decrease in prothrombin time, indicating activation of both the coagulation and fibrinolytic systems following laparoscopic cholecystectomy. Activation of the coagulation system can predispose to thromboembolism, particularly deep vein thrombosis. However, none of the 50 patients in our study experienced such complications. This suggests effective compensatory mechanisms in response to mild changes in the coagulation profile. Larger and more comprehensive studies are needed to further elucidate these changes in the coagulation system and to quantitatively assess the risk associated with laparoscopic cholecystectomy using carbon dioxide pneumoperitoneum.

Recommended Articles

Volume-6, Issue-4

Downloads

Download PDF pdf

Download XML

Citations

214 Views

8 Downloads

Share this article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

All papers should be submitted electronically. All submitted manuscripts must be original work that is not under submission at another journal or under consideration for publication in another form, such as a monograph or chapter of a book. Authors of submitted papers are obligated not to submit their paper for publication elsewhere until an editorial decision is rendered on their submission. Further, authors of accepted papers are prohibited from publishing the results in other publications that appear before the paper is published in the Journal unless they receive approval for doing so from the Editor-In-Chief.

IJMPR open access articles are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. This license lets the audience to give appropriate credit, provide a link to the license, and indicate if changes were made and if they remix, transform, or build upon the material, they must distribute contributions under the same license as the original.