Stiff-Person Syndrome: A Rarity

doi:10.5281/zenodo.15868327

International Journal of Medical and Pharmaceutical Research

2025, Volume-6, Issue-3 doi: 10.5281/zenodo.15868327

Original Article

Stiff-Person Syndrome: A Rarity

Krishna Kumar Goyal

Shubhakaran Khichar

DOI : 10.5281/zenodo.15868327

Published

June 30, 2025

Abstract

Aim: To report a case of stiff-person syndrome presented with paraparesis, musclespasm and newly diagnosed case of Diabetes Mellitus.

Methods and result: A 27 years old female presented to us with complaints of progressive difficulty in walking with intermittent muscle spasm. It was in the form of extensor posturing. Patient also had past history of Diabetes Mellitus. On evaluation patient found to have Stiff-Person Syndrome on the basis of clinical examination, electrophysiology and positive anti GAD-65 antibody. Our patient responded well to IvIG and Inj. Methylprednisolone with symptomatic therapy with diazepam and baclofen.

Conclusion: Here we reviewed the case presentation, diagnostic and therapeutic options for this severe disabling disease. Our case shows treatment strategies for Stiff Person Syndrome on the basis of evidence based studies. As large evidence based studies for treatment of SPS is still lacking, So further observation and large case series will be of use in future.

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