Primary Sjogren’s Syndrome which is an autoimmune disorder can rarely involve kidney resulting in Distal Renal Tubular Acidosis (RTA type I) which can result in severe hypokalemia resulting in flaccid Quadriparesis/Quadriplegia. However Sjogren’s Syndrome primarily presenting with hypokalemic Quadriparesis/Quadriplegia is rare. We report a case of 60 year old lady who presented with rapidly progressive hypokalemic Quadriparesis which responded to treatment with potassium salt was later confirmed to be suffering from Sjogren’s Syndrome.