Background: Elevated serum ferritin levels have been associated with acute myocardial infarction (AMI), but its prognostic significance remains unclear. This study aimed to investigate the serum ferritin levels in patients with AMI and to explore its prognostic importance. Methods: This study involved patients admitted to Navodaya Medical College Hospital and Research Centre, Raichur, with confirmed AMI, and age and gender-matched controls. Serum ferritin levels were measured at presentation and at a 4-week follow-up. Clinical features, co-morbidities, habits, and echocardiographic findings were also recorded. Results: Serum ferritin levels were significantly elevated in patients with AMI at presentation (mean: 319.38, SD: 94.75) and at a 4-week follow-up (mean: 327.99, SD: 105.81) compared to controls (p < 0.0001). There was no significant difference in serum ferritin levels across different categories of left ventricular ejection fraction (p = 0.762103). The presence or absence of co-morbidities such as hypertension and diabetes, and habits like smoking and alcoholism, did not significantly influence serum ferritin levels. Conclusion: Our study suggests that serum ferritin levels are significantly elevated in patients with AMI and these elevated levels persist even at a 4-week follow-up. However, these levels did not correlate with left ventricular ejection fraction or with the presence or absence of certain co-morbidities and habits. Future studies are needed to further explore these relationships and the potential prognostic role of serum ferritin in AMI.