Background: Hypertension is a complex cardiovascular disorder with multifactorial etiology. This study aimed to investigate the association between serum calcium and magnesium levels and hypertension.

Methods: A prospective observational study was conducted with 100 newly diagnosed hypertensive patients and 100 normotensive controls. Serum calcium and magnesium levels were measured, and their correlation with blood pressure was analyzed.

Results: Hypertensive patients exhibited significantly higher serum calcium levels (9.8 ± 0.6 mg/dL) compared to normotensive controls (9.4 ± 0.5 mg/dL, p < 0.001). Conversely, serum magnesium levels were lower in hypertensive patients (1.9 ± 0.2 mg/dL) than in controls (2.1 ± 0.2 mg/dL, p = 0.003). A positive correlation was found between serum calcium levels and blood pressure severity (systolic: r = 0.28, p = 0.004; diastolic: r = 0.19, p = 0.03), while an inverse correlation was observed for magnesium (systolic: r = -0.31, p = 0.002; diastolic: r = -0.25, p = 0.01).

Conclusion: The study highlights the significant association of serum calcium and magnesium levels with hypertension. These findings suggest the potential of serum mineral levels as predictive markers and therapeutic targets in hypertension management.