Introduction: Blood transfusion is a life saving process, how ever, can be proved lethal to the recipient’s by exposing them to the transfusion transmissible infectious pathogens. One of these agents is the spirochete called Treponema pallidum which causes the panic infectious disease “Syphilis”.

Objective: To study the seroprevalence and the demographic profile of syphilis among blood donors at the Blood Bank, ACSR Government General Hospital, Nellore.

Materials & methods: The present study was done retrospectively from January 2021 to June 2023(a two and half year study) in the Department of Transfusion Medicine, ACSR Government General Hospital, Nellore. Before donation each potential donor was made to fill a detailed health history questionnaire, which included data regarding age, gender, address, occupation and other questions concerning the donor’s general health, lifestyle and risk behaviour. All the samples were tested for Transfusion Transmissible Infections (TTI). Prevalence of TTI and syphilis and demographic profile of the donors was analysed.

Results: In the present study the total number of donors are 3592 and the prevalence of TTI is 1.97% (71 out of 3592) and the total number of seropositive cases of syphilis are 22 (0.6%). Out of 3592 donors, 3377 (94%) were voluntary donors and the remaining 215 (6%) were replacement donors. The predominant age reactive for syphilis was 20 -29 years. 16 syphilis positive donors were married and 6 were unmarried. All the syphilis reactive donors are males. 17 donors were from urban area and 5 were from rural area. The rates were found to be high among labourers.

Conclusion: Proper counselling prior to blood donation and awareness about syphilis among blood donors may increase the safety of blood as well as community.