Introduction:Ultrasound is the equipment used to diagnose the disease. Abdominal pain can be classified as visceral, somatoparietal or referred pain that can be a manifestation of a wide array of systemic and local causes. An ultrasound scan could be a medical test that uses high-frequency sound waves to capture real time images of the organ. Different sorts of transducer or probe are used to supply the USG image. Purpose: The aim of this study is to evaluate the role of ultrasonography in different diagnostic conditions of abdomen. Methodology: A quantitative prospective study was performed to assess the role of ultrasonography in abdominal pain in male patients who undergoes abdominal ultrasonography in the radiology department of BSM Medical University Dhaka, Bangladesh from February 2023 to March 2024. 90 male patients were selected according to the inclusion criteria of this study. Patients will be signing a consent before the investigation. History was taken from patients prior to investigation. Abdominal ultrasound was performed. Result: Out of 90 male patients, out of which 21 (23.3%) patients have fatty liver, 12 (13.3%) patients have right renal calculus, 9 (10%)patient have left renal calculus, 3(3.3%)patient have B/L renal calculus, 5 (5.5%) patients have acute pancreatitis, 3 (3.3%) patients have acute appendicitis, 2 (2.2%) patients have liver abscess, 7 (7.7%) patients have cyst, 7 (7.7%) patients have ascites, 19 (21.1%) patients have cholelithiasis and 1 (1.1%) patient have normal. Sonography play key role in to visualized gross primary investigation in abdomen. Conclusion: The study concludes uses of USG should be perform as a primary investigation for all patients. This study has shown a relatively high sensitivity, specificity and diagnostic accuracy of USG in cases of acute abdomen in a careful hand. USG is currently considered the preferred initial imaging technique for patients who are clinically suspected of having fatty liver, renal calculus, acute pancreatitis, acute appendicitis, ascites, cyst, liver abscess and cholelithiasis etc.