Introduction: Platelet transfusion is a lifesaving procedure for thrombocytopenia, can be either prophylactic or therapeutic. Evaluation of the response to platelet transfusion by calculating Corrected count increment (CCI).The corrected count increment (CCI) is a laboratory evaluation of the effectiveness of Platelet concentrate transfusion. Corrected count increment (CCI) is the most widely used surrogate marker for evaluating refractory patient’s responses to platelet component transfusions which is measured at 24 hour post transfusion.Aim and Objectives: 1) To study the number of platelet transfusion that was done during the study period. 2) To study the indications for the platelet concentrate transfusions in cases of thrombocytopenia. 3) To evaluate efficacy of platelet concentrate transfusion for increment of platelet count. 4) To evaluate the causes of refractoriness to platelet transfusion. Material and Methods:The present study included 100 cases having thrombocytopeniaadmittedat SMIMER hospital whoreceived platelet concentrate transfusion during the study period from 1st June 2024 to 31st November 2024.Patient information was collected from blood bank component register and from ward.Investigations including pre and post transfusion platelet counts were noted using following formula, Results: Majority of the platelet recipient were transfused prophylactically when platelet count were > 20000/ul. The most common among them is infectious causes. The most common category of diagnosis among these patients was infectious agent. Conclusion: The usage of platelet concentrates in thrombocytopenia found in the study reveals infectious cause as predominant and common finding.CCI values is found to be useful in evaluating response in cases of thrombocytopenic patients receiving platelet concentrate transfusion.It was noticed that platelet count does not increase to the expected level after platelet transfusions in certain patients due to refractoriness to the platelet transfusion (in cases of fever, sepsis etc).