Background: Hyperuricemia (elevated serum uric acid) has been increasingly reported to associate with components of the metabolic syndrome (MetS) — central obesity, dyslipidaemia, hypertension and insulin resistance. There is uncertainty about the strength and independence of these associations in different populations. Data from the north coastal Andhra Pradesh region are limited. Hence the present study aims to estimate the prevalence of hyperuricemia among patients with metabolic syndrome (MetS) and in age and Gender matched controls and also to study the association between serum uric acid (SUA) levels and individual MetS components.

Methodology: The study compared 50 patients with metabolic syndrome diagnosed according to IDF criteria from the Endocrinology Outpatient Department at King George Hospital, Visakhapatnam to 30 age and Gender matched healthy controls. Serum uric acid levels and metabolic parameters (waist circumference, triglycerides, HDL-C, fasting plasma glucose, and blood pressure) were evaluated.

Results: Serum uric acid levels were significantly higher in metabolic syndrome patients than in controls. Uric acid showed positive associations with waist circumference, triglycerides, and hypertension, but no significant correlation with HDL-C or fasting glucose. Levels were higher in males and rose with the number of metabolic syndrome components.

Conclusion: Serum uric acid is significantly elevated in metabolic syndrome and shows positive associations with central obesity, hypertriglyceridemia, and hypertension, suggesting its potential role as a metabolic risk marker.