Leprosy, or Hansen’s disease (HD), is a bacterial disease caused by Mycobacterium leprae [1,2] that continues to be a significant health problem in many parts of the world. It produces a chronic infection in humans that affects mainly peripheral nerves and skin but may also affect sites such as eyes, mucous membranes, bones, and testes.2,4 According to National Leprosy Eradication Program India has prevalence of less than 1 case of leprosy per 10,000 population and has reported 1,63,672 new cases in 2021-2023 [5].In the present study, we analyzed the differenthistomorphological patterns of leprosy among patients at Era’s Lucknow Medical College and Hospital. Data were collected from the medical records in the Department of Pathology, focusing on 121 clinically diagnosed cases of leprosy from January 2021 to June 2023.By analyzing these different types, the study aims to enhance understanding of leprosy's manifestations in this region, which may aid in improving diagnosis, treatment, and public health strategies for managing the disease.