Background: Digital screen use has become ubiquitous in modern workplaces, potentially increasing the risk of dry eye syndrome (DES).Objective: To determine the prevalence of DES among urban office workers and identify associated risk factors, particularly focusing on screen time and workplace environmental conditions.Methods: A cross-sectional study was conducted among 460 office workers using digital screens. Participants underwent comprehensive ophthalmic examination including tear break-up time (TBUT) and Schirmer's test. Environmental factors were measured, and symptoms were assessed using the Ocular Surface Disease Index (OSDI).Results: The prevalence of DES was 53.9% (95% CI: 49.3-58.5%). Mean daily screen time was 8.5 ± 1.7 hours. DES prevalence increased significantly with screen time (p<0.001), from 39.1% in those using screens 6-7 hours to 69.4% in those exceeding 9 hours daily. Multivariate analysis identified significant risk factors including female gender (OR=1.6, p=0.002), low humidity (OR=2.1, p<0.001), and close screen distance (OR=1.7, p=0.012).Conclusion: DES is highly prevalent among urban office workers, with screen time duration and workplace environmental factors serving as significant modifiable risk factors. Implementation of workplace environmental modifications and screen time management strategies may help reduce DES prevalence.