INTRODUCTION: Hemoglobinopathies may be either qualitative or quantitative defects of hemoglobin. The major hemoglobinopathies consist of Thalassemias (mainly alpha and beta) and variant haemoglobins (HbS, HbE, HbD, Punjab etc.). India has the largest number of children with Thalassemia major in the world – about 1to 1.5 lakhs and almost 42 million carriers of Beta thalassemia trait. About 10,000 – 15,000 babies with Thalassemia major are born every year. Pregnancy with hemoglobinopathies are at very high risk.

METHOD: This prospective cross-sectional study was conducted on pregnant females attending ANC (Anti Natal Care) OPD in Dhiraj Hospital, Vadodara for a period of one year (1 year) from July 2022 to July 2023. Consenting participants were interviewed using a pre-constructed questionnaire. All the data were charted and tabulated according to  mentioned parameters like Name, Age, Address, Socioeconomic status sibling history, consanguinity, any family history of blood disorder etc.

RESULTS: The total number of pregnant women screened for hemoglobinopathies was 500 from the ANC OPD of Dhiraj Hospital, Piparia from July 2022 to June 2023. 475 out of total 500 women were positive for hemoglobinopathies. Out of these, 86% were positive for sickle cell trait while 7% showed sickle cell disease and 2% were positive for Beta thalassemia trait on the basis of their HPLC test result. In our study majority of Women demonstrated mild anaemia (60%) while Moderate (36%) and severe (4%) anaemia were seen in a total of 40 pregnant women, which is additional finding observed.

CONCLUSION: In the present study, gravid population has higher prevalence of hemoglobinopathy (95%) mainly Sickle cell trait (86%). More efforts are required to increased awareness in high risk populations concerning hemoglobinopathies before in order to control it in India