Background: To determine the Presepsin level in clinically suspected neonatal sepsis.To Evaluate the efficacy of Presepsin as a early diagnostic marker of sepsis with previously existing other neonatal sepsis markers like CRP, Total leucocyte count, Platlet count.To correlate Presepsin with conventional blood culture method for diagnosis of neonatal sepsis.

Methods: Blood samples were taken from 100 clinically suspected neonatal sepsis and were processed for blood culture, detection of serum level of CRP by latex agglutination test and detection of serum level of PRESEPSIN by ELISA

Results: In the present study, Serum C-Reactive protein was elevated in 16 out of 29 culture proven sepsis. The Abnormal WBC count was seen in 7 out of 29 cultures with proven sepsis and Platlet count was reduced in 12 out of 29 neonatal sepsis .Presepsin was elevated in 24 out of 29 cultures with proven sepsis. The sensitivity of Presepsin in detecting sepsis was 82.8%, its specificity was 77.5%, its positive predictive value was 60% and its negative predictive value was 41.4%.

Conclusion: The estimation of Presepsin also helps in avoiding unnecessary antibiotic usage where it is not required and thereby reducing the hospital cost and the occurrence of bacterial resistance. Estimation of Presepsin could be a milestone in the continuing research for a definitive diagnostic biomarker in neonatal sepsis.