Introduction: Parathyroid adenoma is part of a spectrum of parathyroid proliferative disorder that includes parathyroid hyperplasia, parathyroid adenoma, and parathyroid carcinoma. Patients typically present with evidence of primary hyperparathyroidism with elevated serum calcium levels and elevated serum parathyroid hormone levels. 8 patients with parathyroid adenoma are presented in this study describing their presentations, clinical profiles, and management.

Materials and Methods: It is a case series retrospective review of 8 cases of parathyroid adenoma conducted at MS Ramaiah Medical College Hospital, Bangalore from october 2020 to june 2022.

Results: Eight cases of operated parathyroid adenoma were included in the study, out of which, 2 were male and 6 were female. 4 patients had an incidentally detected parathyroid adenoma while rest of the patients presented with generalised weakness, bony pain and abdominal pain. Serum calcium ranged from 9.6 mg/dl - 13.2 mg/dl (Mean ± SD - 11.26 ± 1.09 mg/dl). Serum PTH ranged from 427 pg/ml - 2161 pg/ml (Mean ± SD - 840.5 ± 559.11 mg/dl). Technetium-99m methoxyisobutylisonitrile (99mTc MIBI) scintigraphy picked up a single parathyroid adenoma wherein 6 of these cases, right-sided parathyroid was involved and left parathyroid adenoma was seen in 2 patients. All the patients underwent parathyroid adenoma excision under GA. Decrease in more than 50% of baseline PTH confirmed the excision of parathyroid adenoma. Intra operative PTH ranged from 57.6 pg/ml - 287.2 pg/ml (197.01 pg/ml). The postoperative period for all these patients was uneventful. There was definitive symptomatic improvement after parathyroidectomy.

Conclusion: The study showed association of diabetes in 4 cases and 4 cases of asymptomatic parathyroid adenoma were incidental findings. In the remaining cases, there was strong clinical suspicion, supported by biochemical evidence, which was then confirmed by 99mTc MIBI scintigraphy. The diagnosis of a parathyroid adenoma was strengthened by 99mTc MIBI scintigraphy and later supported by histological analysis. In each of these cases, there was a clear indication for surgery, and following the procedure, symptoms began to improve.