Background: Laparoscopic cholecystectomy (LC) is the preferred surgical approach for symptomatic gallstones. In cases of choledocholithiasis, preoperative endoscopic retrograde cholangiopancreatography (ERCP) is performed for common bile duct (CBD) clearance. However, ERCP-induced inflammation and fibrosis may complicate subsequent LC.

Objective: To assess the safety, feasibility, and outcomes of LC performed after successful ERCP for CBD stone clearance.

Methods: A retrospective analysis was conducted on 157 patients undergoing LC following ERCP from January 2021 to July 2025 at GMC Srinagar. Data collected included patient demographics, ERCP characteristics, interval between ERCP and LC, intraoperative findings, and postoperative outcomes.

Results: The cohort had a female predominance (66.9%) with a mean age of 45.7 ± 12.4 years. The interval between ERCP and LC averaged 6.3 ± 3.1 weeks. LC duration averaged 68 ± 21 minutes. Intraoperative complications included hemorrhage (2.5%) and gallbladder perforation (7%). Postoperative complications were low: surgical site infection (4.4%) and residual CBD stones (2.5%). No bile duct injury, bile leak, conversion to open surgery, or mortality was observed. Operative difficulty was noted in 29% of cases based on adhesions and distorted Calot’s triangle.

Conclusion: LC post ERCP is safe and feasible when performed by experienced surgeons. A waiting interval of 4–6 weeks may optimize operative conditions and reduce perioperative risk.