Background: Cerebral Nocardiosis is rare but very severe infection that carries high mortality rate in immune compromised patients. It often results in intraparenchymal abscess formation which represents only 2% of all cerebral abscesses. Early suspicion and confirmation of diagnosis are required to prevent morbidity and mortality. Case: A 60-year-old immune compromised female patient had a fall followed by left upper & lower limb weakness. Cerebral abscess was found in right parietal region which was drained & sent for culture & sensitivity. Conclusion: Nocardia should be considered as one of the differential diagnosis in immune compromised patients presenting with neurological complaints. Speciation of Nocardia is very important as N. farcinica is a fast-emerging pathogen with multidrug resistance.