Central diabetes insipid us (CDI) is a syndrome by polyuria and polydipsia. This is attributed to arginine vasopressin (AVP), an anti-diuretic hormone that acts on kidney V2 receptors to enhance the re-absorption of free water. We reported a rare case of patient presenting with signs of polyuria and polydipsia which have a wide differential diagnoses of which CDI should not be neglected. Effective treatment can Improve the prognosis if diagnosed in time, We provide a summary of clinical findings, pathological features, brain imaging and laboratory investigations. We also discuss treatment strategies and approaches to monitoring the therapeutic response. lastly, we briefly summaries the current understanding of the path physiology ٦of the disease.