Background: Community acquired Staphylococcus Aureus causing neurological manifestations is rare. Very few reports document presentations and outcomes of this disease. We present, a series of 4 patients with neurological manifestations of spontaneous community acquired Staphylococcal Aureus admitted to an adult intensive care unit (ICU)over one year period. Patterns of community acquired Staphylococcal Aureus related neurological manifestations, from different regions are needed to draft evidence based management guidelines.

Objectives: To document clinical, laboratory and radiological findings in a cohort of community acquired Staphylococcal Aureus patients hospitalised with neurological manifestations and compare their presentation and outcomes with previously published cases available.

Study design: Clinical, laboratory, demographic information and outcomes were collected from patients with confirmed CNS infections of community acquired Staphylococcal Aureus treated in an ICU, in a tertiary care hospital, from September 2021- August 2022.

Results: The case series had a male predominance(75%) and the mean age was 61.3 yrs. All 4 patients were diabetics.75% had an epidural abscess but none had features of infective endocarditis. All patients were positive for MRSA in blood and pus. They were treated with parenteral Vancomycin and surgical decompression whenever indicated. Out of the 4 patients 2 improved and were discharged, 1 patient was transferred to another centre and 1 patient died.

Conclusion: Awareness of neurological manifestations of community acquired Staphylococcal Aureus should allow its early recognition and institution of appropriate treatment. Reports on community acquired Staphylococcal Aureus, from different regions will help in formulating more evidence-based guidelines, for optimum evaluation and care of such patients. Our data contributes towards this goal.