Neuroendocrine Carcinoma of Gallbladder is a rare tumor, which is heterogenous neoplasm originating from neuroendocrine cells, which secrete neurotransmitter. Among all theneuroendocrine neoplasms, gallbladder neuroendocrine neoplasm prevalence is 0.5% accounting for approximately 2.1% of all the gallbladder tumors. Case Presentation As gallbladder neuroendocrine neoplasm is a rare lesion it is seldom seenin clinical practice, there is a limited availability of review reports and it is therefore often considered only as a case study. It is difficult to distinguish gallbladder neuroendocrine neoplasms from other gallbladder diseases using imaging diagnostic techniques. We here report a case of 55 years old female presenting with right upper quadrant and epigastric pain and eventually diagnosed with mixed cell neuroendocrine carcinoma of gallbladder. Conclusion Therefore to overcome inherent risks or shortfalls of traditional surgery, early detection, diagnosis and treatment of gallbladder neuroendocrine neoplasms are required to improve patient longevity.