Background: Musculoskeletal disorders (MSDs) are a significant occupational health concern among nursing staff, leading to reduced productivity, increased absenteeism, and compromised patient care. This review aims to synthesize the evidence on the effectiveness of multimodal interventions in preventing and managing MSDs among nurses.Methods: A systematic literature search was conducted using PubMed, CINAHL, Embase, and Scopus databases to identify studies examining the effectiveness of multimodal interventions for MSDs in nursing staff. The search included randomized controlled trials, quasi-experimental studies, and pre-post intervention studies published from inception to the present date. Data extraction and quality assessment were performed independently by two reviewers.Results: The synthesis of evidence from the included studies demonstrated that multimodal interventions combining ergonomic modifications, exercise programs, educational strategies, and organizational support were more effective than single interventions in reducing MSD symptoms and risk factors among nurses. Key components of successful interventions included workplace ergonomic assessments, patient handling equipment and training, stretching and strengthening exercises, and participatory approaches involving nurses in the planning and implementation of interventions.Conclusion: The findings of this review support the effectiveness of multimodal interventions in preventing and managing MSDs among nursing staff. Healthcare organizations should prioritize the implementation of comprehensive MSD prevention programs that address the multifactorial nature of these disorders. Further research is needed to establish standardized outcome measures and evaluate the longterm sustainability and cost-effectiveness of multimodal interventions in diverse nursing settings.