Background: Iron and folic acid supplements are a key intervention and mandatory for all antenatal women, irrespective of their haemoglobin status, because as gestational weeks increase, nutrition alone is insufficient to meet the demands. On the other hand, the prevalence of anaemia remains persistently high, with 52% of antenatal women being anaemic, according to NFHS-5. IFAS has shown significant benefits in reducing maternal and foetal complications. Objectives: The aim of this study was to estimate the magnitude of anaemia and assess knowledge about Iron and Folic Acid Supplements (IFAS) among antenatal women. Methods: An observational, descriptive cross-sectional study was conducted among 142 antenatal women selected by convenience sampling at Government General Hospital (GGH), Kurnool. Sahli's method was used for haemoglobin estimation, and a structured questionnaire was used to assess knowledge after obtaining informed consent. Results: Out of 142 antenatal women, 45% belonged to the 18–21-year age group, 50.7% were primi’s, and 49% were multigravidas. The magnitude of anaemia among antenatal women was normal, mild, moderate 27.4%, 61.9% and 10.56% respectively. The proportion of antenatal women having good, fair, and poor knowledge about IFAS was 0.7%, 52.8%, and 46.4%, respectively. Conclusion: The study revealed that the majority of antenatal women 61.9%were anaemic, with only 27.4% having normal haemoglobin levels. Furthermore, 46.4% of the women had poor knowledge about IFAS..Hence should focus more on Information, Education and Communication activities(IEC).