One of the most prevalent dermatological conditions is psoriasis, a chronic inflammatory condition. Although it is linked to a number of illnesses, cardiovascular disease is the most prevalent. Since lipid abnormalities are seen in psoriasis sufferers early on, the condition may be genetically resolved. Therefore, it is crucial to investigate lipid abnormalities in psoriatic patients in order to assess the risk of atherosclerosis and vascular obstructive disorders, as well as the morbidity and mortality that go along with them. Aim: Estimating lipoprotein levels and associated cardiovascular disease risk in psoriasis patients. Materials and Methods: This crosssectional analytical investigation is centered in the community. The healthy ambulatory population in and surrounding Jay Prabha Medanta Super Specialty Hospital in Kankarbagh, Patna, Bihar, comprised the study population.40 psoriatic patients with a mean age of 50.68 ± 8.86 years made up the study group, while 40 healthy people of either sex with a mean age of 50.15 ± 9.6 years made up the control group. There were 55% males and 45% females in the control group and 59% males and 41% females in the test group. estimation of serum triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol the same day, lipoprotein levels were measured. The Enzymatic End Point Method is used to estimate the amounts of lipoproteins. The mean, standard deviation, p-value, and Chi-square test were computed in order to analyze the data. Results: Psoriasis patients had significantly higher levels of VLDL and total cholesterol than control subjects (p<0.05). Serum TG results showed a significantly significant difference between psoriasis sufferers (6.8 ± 1.49) and controls (3.08 ± 1.3) (p<0.001). Serum LDL levels in psoriasis patients and controls did not differ significantly, though. Serum HDL levels did not significantly alter in either the control group or the psoriasis patients. While there were no discernible changes in the LDL/HDL ratio between the psoriasis case and control, there was a statistically significant difference in the TC/HDL ratio (p<0.05). Conclusion: According to the current research, hyperlipidemia was linked to psoriasis patients. Thus, they are at a significant risk of getting cardiovascular disorders. We propose that assessing psoriatic patients' serum lipid profiles will aid in early risk assessment. Cardiovascular problems can be avoided in these patients with quick therapy.