International Journal of Medical and Pharmaceutical Research
2023, Volume-4, Issue-5 doi: 10.5281/zenodo.10009496
Original Article
Lipid Peroxidation, Oxidative Stress and Its Correlation with Glycated Hb in Type2 Diabetes Of North West Punjabi Population
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Published
Oct. 16, 2023
Abstract
Background: In India, type 2 diabetes mellitus(DM) is an epidemic disorder because of social impact and changes in way of life. According to the WHO, 72 million people were affected by DM in India in the year 2017, a figure expected to almost double to 134 million by 2025, the largest number in any country in the world. Aims and Objectives: The aim is to investigate the Lipid Peroxidation, Oxidative stress and its correlation with Glycated Hb in Type2 Diabetes of North West Punjabi population. Material and Methods: This cross- sectional study included 200 subjects, 100 were type 2 diabetic patients and 100 were healthy non-diabetic individuals. The data were analyzed using a t test. Results; The results showed positive correlation between HbA1c and fasting blood Glucose (r = 0.417, p= 0.000) with MDA(r=0.340,p=0.000), Triglycerides (r = 0.214, p= 0.003), Total cholesterol(r= 0.306,p=<0.002), Non HDL(r=0.322,p=0.001), LDL(r=0.327,p=0.001), VLDL(r=0.318,p=<0.001), with glycated Hb in patients of type 2 diabetes mellitus. Similarly, with HbA1c and with BMI (r= 0.422,p=0.000) with glycated Hb in patients of type 2 diabetes mellitus, Whereas negative correlation was observed between HbA1c and other parameters like HDL (r=0.197, p=0.050), HDL to LDL ratio(r=0.144,p=0.152), SOD (r=0.025,p=0.803). Conclusion; As glycemic control of diabetic patient decreases, this increase of glycated Hb leads to atherogenic lipid profile along with increased lipid peroxidation, thus making the individual susceptible to various complications, both macrovascular and microvascular.
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