Lemiere’s syndrome is a rare but life-threatening condition which is most often preceded by an oropharyngeal infection. The most common organism involved is fusobacterium necrophorum, which is a part of normal flora of oropharynx. This case report describes a rare case of Klebsiella oxytoca associated Lemiere’s syndrome in a patient with poorly controlled Diabetes Mellitus. To our knowledge there has been only one single reported case of Lemiere’s syndrome caused by Klebsiella Oxytoca and this should be considered among the possible organism causing Lemiere’s syndrome. Though rare Lemiere’s syndrome carries a high mortality rate. Therefore clinicians should be familiar with signs and symptoms of the disease as well as the preemptive examinations, procedures and treatments.