Introduction: Acute Phase proteins, which is part of a repertoire of cell responses to inflammation, can be used as diagnostic tool and may provide an alternative means of monitoring health. In this study, we aimed to explore the role of Serum Amyloid A (SAA) protein and other inflammatory markers like CRP, Ferritin, LDH, D-Dimer and Lymphocytes in acute and convalescent phase of SARS–Cov-2 cases. Methodology: In this pilot study, 5ml of blood sample was taken from 30 SARS CoV2 positive patients and Serum inflammatory markers like SAA, CRP, D-Dimer, Ferritin, and Lactate dehydrogenase & Lymphocytes were estimated. According to the MOHFW guidelines, 16 out of 30 were categorized as non-severe Covid-19 and 14 of them as severe Covid-19 who had SPO2<90% or RR> 30/minute. There were 7 deaths out of the total 14 severe Covid-19 Results: SAA is elevated in acute phase (AP), and is decreased in convalescent phase (CP), with statistically significant p value (p<0.01). All other inflammatory markers exhibit similar pattern with a statistically significant p values between acute and convalescent phase except for inverse relation of Lymphocytes. Lymphocyte counts were strongly and significantly correlating with disease severity than compared to other inflammatory markers. Lymphocytes, ferritin and D-Dimer levels during admission also significantly correlates with mortality. Conclusion: Serum SAA level is significantly increased in acute phase along with other inflammatory markers like CRP, Ferritin, LDH, D Dimer and lymphocyte count. But serum ferritin, D-Dimer and lymphocyte counts at baseline can be used to predict the worse outcome.