Introduction: Family members especially their spouses suffer intense psychological, physical and social trauma due to core drinking problem. Intimate partner violence (IPV) is a globally acknowledged public health problem. In this background the study was carried out to assess IPV and depression in spouses of Alcohol Dependence Syndrome (ADS). Methodology: A hospital-based study of 100 participants with alcohol dependence syndrome and their spouses were interviewed. Patient with other psychiatric illnesses and substance dependence except nicotine were excluded. Spouses diagnosed with any psychiatric illness were excluded. Severity of alcohol dependence questionnaire (SADQ) Hamilton depression rating scale (HAM-D) and Hamilton anxiety rating scale (HAM-A) were used for the participants and WHO-IPV scale was used for their spouses. Results: A positive association of the severity of alcohol consumption with IPV. We also found a significant association with HAM-A and HAM-D to spouse who were exposed to IPV. Conclusion: This study highlights that depression and anxiety disorders co-morbid in patients with ADS and IPV is higher spouses of patients with ADS.