Background: Preeclampsia is an acute complication of pregnancy characterized by hypertension, proteinuria, and other organ disorders occurring after 20 weeks of gestation. Early detection of preeclampsia is crucial to avoid complications and poor prognosis. The association between increased uric acid concentration and preeclampsia has been recognized since the early 1900s. The classic interpretation of elevated uric acid levels suggests that the vasoconstriction mechanism of blood vessels due to hypertension can reduce kidney clearance. This study aims to analyze the differences in blood uric acid levels in pregnant women with preeclampsia and normal pregnant women.

Methods: The research method used is a case-control design, with 10 blood samples from normal pregnant women as the control population and 10 blood samples from pregnant women with preeclampsia as the case population. Preeclampsia data were obtained from patients' medical records, whereas uric acid level data were obtained from laboratory tests. Bivariate analysis was performed using T-test.

Results: The results of this study show that the case group has a higher uric acid level (68.1%) compared to the control group (31.9%).

Conclusions: Based on bivariate analysis, the p-value is <0.05, indicating a significant difference in uric acid levels between pregnant women with preeclampsia and normal pregnant women.