Importance of Speciating Aspergillusfrom Clinical Samples and Interpretation of Antifungal Susceptability Results

doi:10.5281/zenodo.8002490

International Journal of Medical and Pharmaceutical Research

2023, Volume-4, Issue-3 doi: 10.5281/zenodo.8002490

Original Article

Importance of Speciating Aspergillusfrom Clinical Samples and Interpretation of Antifungal Susceptability Results

Almas Fathima Upaisal

Anupma Jyoti Kindo

Prasanna Kumar Saravanam

V Lakshmi Sree

DOI : 10.5281/zenodo.8002490

Published

June 4, 2023

Abstract

Background: Aspergillosis caused by different species might affect the choice of treatment in certain species depending upon the MIC values.The aim of this study was to determine the antifungal susceptibility pattern among dif-ferent Aspergillus species to the routinely used antifungal agents in accordance with CLSI M38 A. Methods: Aspergillus grown from various clinical sample was subcultured and identified phenotypically. Antifungal susceptibility testing (AFST) was done for 5 antifungal agents- AmphotericinB, Voriconazole, Posaconazole, Itraconazole and Caspofungin. Results: Aspergillus flavus was the predominantly isolated speies. Aspergillus flavus and Aspergillus niger showed high MIC values to AMB & ITR and low MIC for VOR & POS. Some species of Aspergillus flavus exhibited rare phenomenon like paradoxical/trailing effect. Aspergillus fumigatus showed low MICs for both triazoles and AMB. Aspergillus terreus had high MIC for triazoles and AMB. All of the tested isolates showed low MECs against caspofungin. Conclusion: Aspergillus is a fungal pathogen which is easy to treat unless it is invasive. Variation in susceptibility profile noted for the Aspergillus for each species to the common antifungal agents; since the azole resistance is in increasing trend hindering the effective antifungal therapy resulting in therapeutic failures.

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