Background: High-risk pregnancies are associated with an increased incidence of placental abnormalities. Histopathological examination of the placenta provides valuable insights into the underlying pathophysiology of adverse pregnancy outcomes. Objectives: To investigate the histopathological changes in the placentas of high-risk pregnancies and to analyze the associations between specific high-risk conditions and histopathological findings. Methods: A total of 100 placentas from high-risk pregnancies were examined in this observational study. The prevalence of histopathological findings and their associations with specific high-risk conditions were analyzed using appropriate statistical tests. Results: The mean maternal age was 28.7 ± 5.6 years, and the mean gestational age at delivery was 36.8 ± 3.4 weeks. Syncytial knots were the most common histopathological finding (55%), followed by calcification (40%), fibrinoid necrosis (35%), villous hypermaturity (28%), infarction (25%), chorioamnionitis (18%), and villous hypomaturity (12%). Significant associations were observed between gestational diabetes mellitus and syncytial knots (68.2%; p=0.045), hypertensive disorders of pregnancy and fibrinoid necrosis (60.0%; p=0.002), IUGR and villous hypomaturity (44.4%; p=0.001), and preterm delivery and chorioamnionitis (40.0%; p=0.028). Conclusion: This study demonstrates significant associations between specific high-risk pregnancy conditions and certain histopathological findings in the placenta. These findings underscore the importance of placental examination in the evaluation of high-risk pregnancies and provide a foundation for future research to improve maternal and fetal outcomes.