Background: Vesiculobullous lesions present with fluid filled cavity within or beneath the epidermis or mucous membrane or both. Various type of pathologic process includes inflammatory, autoimmune, infective, drug induced or genetic causes can lead to development of vesiculobullous eruption. Methods: In this study 65 clinically diagnosed cases of vesiculobullous lesions were included from January -2019 to December -2022. Clinical data like age, sex, duration & site of lesion, history of any disease or drug, any significant family or personal history noted. Punch biopsy has been taken and after processing and staining with haematoxylin-eosin it was examined under the microscope. Results:Vesiculobullous lesions were seen among 5 years to 92 years of age. Out of 65 cases 35 were male and 30 females. In present study Pemphigus Vulgaris was most common -16 cases (24.6%) followed by Bullous Pemphigoid -13 cases (20%). 10 cases of Pemphigus Foliaceus, 8 cases of Steven Johnson Syndrome & 4 cases each of Hailey Hailey disease & Linear IgA dermatosis were reported. 3 cases each of Dermatitis herpetiform&Darier’s disease were also reported – less common lesion include Sub corneal pustulardermatosis, Bullous fixed drug reaction (1 case each). In 2 cases of vesiculobullous lesions further Direct Immunofluorescence technique (DIF) required to confirm accurate diagnosis.Conclusion: Histopathological examination along with clinical correlation is required to confirm the diagnosis of vesiculobullous lesions and in some cases, direct immunofluorescence is required for final diagnosis.