International Journal of Medical and Pharmaceutical Research
2024, Volume-5, Issue-6 doi: https://doi.org/10.5281/zenodo.14258155
Original Research Article
HbA1c Levels in PCOS-IR Rats (Rattus Norvegicus) Models After Administration of Moringa oleifera Extract
Published
Dec. 2, 2024
Abstract

Abstract: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder characterized by irregular ovulation and the presence of small cysts on the ovaries. This condition is frequently associated with obesity, insulin resistance, and diabetes. Aim: This research aims to investigate the effects of Moringa oleifera leaves extract on HbA1c levels in white rats (Rattus norvegicus) that have been induced to model insulin-resistant PCOS. Moringa oleifera has various bioactive compounds such as flavonoids, that function as insulin sensitizers, which help improve glucose uptake. Method: This research employs a laboratory experimental design using female rats as subjects. The rats were divided into three groups (n=10): normal rats, PCOS-IR rats (received an intraperitoneal injection of testosterone at a dose of 1 mg/100 g BW for 21 days), and PCOS-IR rats with Moringa oleifera (received the same testosterone injection for 21 days followed by an administration of 500mg/kg Moringa oleiferaleaves extract for an additional 21 days).Blood samples are subsequently collected and analyzed for HbA1c, and the gathered data will undergo statistical processing. Results: The PCOS-IR group exhibited higher HbA1c levels than the negative control group, while the group treated with Moringa oleifera demonstrated significantly lower HbA1c levels than the PCOSIR group. The HbA1c levels in the Moringa oleifera treated group approached those of the control group. Conclusion: This research indicates that the 96% ethanol extract of moringa leaves may provide an effective alternative treatment for managing metabolic issues associated with PCOS-IR, particularly in relation to HbA1c levels.

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