Background: Tuberculosis, the disease caused by Mycobacterium tuberculosis, is recognized as a global public health problem. Post Tuberculosis sequelae are the anatomical and pathophysiological changes in the respiratory system which occurs secondary to complications of pulmonary TB, whether primary or secondary, even after completion of treatment and complete bacteriological cure. Accurate estimates of the frequency and the extent of the pulmonary impairment from tuberculosis are important to patients and clinicians. Hence, it is necessary to assess the extent of the pulmonary function abnormalities among patient who have successfully completed the treatment for pulmonary tuberculosis.
Objectives: To assess the type and grade of airway obstruction in patients who are successfully treated for pulmonary tuberculosis attending Respiratory Medicine department.
Methodology: Cross-sectional hospital based observational study was conducted for a period of one and a half years between February 2021 to July2022 in a tertiary care at Agartala Tripura. All the patients with past history of treated tuberculosis attending in the Department of Respiratory Medicine (OPD & IPD), Agartala Govt. Medical College & G.B.P. Hospital from February 2021 to July 2022 were included in the study fulfilling inclusion and exclusion criteria. During this period spirometry was performed among 152 patients.
Results: The study found that the predominant residual respiratory symptom was shortness of breath (146; 96.1%). This was followed in a descending order by cough (108; 71.1%), haemoptysis (23; 15.1%) and chest pain (58; 38.2%). Among 152 cases, 109 cases were found to have abnormal spirometric patterns. Different age group distribution between 32 different spirometric pattern was not significant (p>0.05). The different spirometric pattern found was involving 67 (44.08%) with obstructive pattern, 27(17.76%) with restrictive pattern, 15(9.87%) with mixed pattern and normal patterns found in 43(28.29%) patients. Majority of the patients 43 cases (64.18%) with obstructive spirometric pattern had severe obstruction. 4 (5.97%) cases had mild obstruction; 20(29.85%) cases had moderate obstruction. Among the recruited patients with abnormal spirometric pattern, 22(20.18%) cases showed significant bronchodilator reversibility (BDR) response and 87(79.82%) cases showed non-significant bronchodilator reversibility response.
Conclusion: The study found that pulmonary tuberculosis irrespective of duration of treatment and outcome of the disease does not correlate with the pulmonary function. It was also found that many of the post-pulmonary tuberculosis patients have persistent respiratory symptoms with obstructive lung disease being the most predominant lung function impairment.