Purpose: To compare the effectiveness of intralesional triamcinolone acetonide and incision & curettage in the treatment of chalazion. Patients and methods: A comparative and randomized study performed on patients with chalazion .Depending on the size of chalazion, patients were distributed in two groups, patient with small sized chalazion (1-4mm) and medium sized chalazion (5-7mm), and based on treatment modality these groups were further subdivided into two groups of 30 patients each with one receiving injection triamcinolone acetonide and other undergoing incision and curettage.Results: 96.70% of patients in Triamcinolone acetonide and Incision and curettage who had size of lesion between 2-4 mm showed complete resolution. This association was not significant. 73.30% of the patients who had size of lesion 5-7 and were given Triamcinolone acetonide showed complete resolution as compared to 93.30% of the patients who underwent Incision and curettage. This association was statistically significant (p=0.038). Conclusion: Triamcinolone acetonide injection proves effective in treating chalazion. This simple and cost-effective procedure can be viewed as an alternative primary treatment option. This method of Triamcinolone acetonide injection, offers a strategy with minimal discomfort and recovery time, hence making the patient more compliant.