Background: Post-operative pain management is a major concern in TKA. Periarticular infiltration in TKA is a technique in which a cocktail of drug combination is injected into the periarticular soft tissues such as posterior capsule, medial and lateral collateral ligaments, quadriceps mechanism, and peripatellar tissue at the end of the surgery. Recent studies found that periarticular injection significantly improved pain relief from 24hr to 1wk and straight leg raise in the early postoperative period. Therefore in our study, we evaluated a combination of local anaesthetic (Ropivacaine), alpha agonist (clonidine), cox-2 inhibitor (ketorolac) as a multimodal analgesic to effect on various pain receptors. We also added epinephrine to reduce their absorption and prolongation of their effect (analgesics).Methods: This study was conducted on 80 patients who were randomly divided into 2 groups, group’s 42 patients (received local infiltration analgesia) and group c 38 patients (received normal salineinjection) based on softwarederived random numbersequence. The data was revealed to the investigators at the end of the study. The statistical analysis of the data set was performed with KolmogorovSmirnov test (p < 0.05) for normality and an unpaired-t test was used to compare mean of the group for the significance of differences of outcome variable. Dichotomous data were analyzed using chi-square test or Fisher’s exact test, as appropriate. A p-value of< 0.05 was considered statistically significant. Results: We observed that the mean VAS score in Group S was lower (2.57) as compared to the Group C (4.66). Patients in group ‘S’ were more satisfied and felt less pain with increased range of motion andphysiotherapy. The patients in group ‘S’ were discharged earlier as they had less pain on physiotherapy as well as on rest and also there is increased mobility of knee joint. Conclusion: Our study suggests that periarticular injection of cocktail of drugs is a safe and effective multimodal analgesia technique that can be used for the management of pain in patient of total knee arthoplasty.