Background: Diabetic ulcers are a significant complication of diabetes mellitus, often leading to prolonged healing and increased healthcare burden. This study aims to evaluate the efficacy of Carica papaya pulp in the management of diabetic ulcers. Methods: A prospective interventional study was conducted on 50 diabetic patients with chronic ulcers, admitted to the Department of General Surgery at Karpaga Vinayaga Institute of Medical Sciences, Chengalpettu, between November 2023 and November 2024. After initial standard wound care, patients received papaya pulp dressings for wound management. The primary outcomes measured were ulcer surface area reduction, granulation tissue formation, graft uptake, and duration of hospital stay. Results: The mean age of patients was 51.82 ± 7.94 years, with 72% male and 28% female. The mean surface area of the ulcers decreased from 56.68 cm² to 33.74 cm² post-treatment. Granulation tissue formation reached 43.08% of the ulcer area after 10 days. Graft uptake on the 5th postoperative day averaged 66.84%, and the average duration of hospital stay was 49.50 ± 11.22 days. Female patients showed slightly higher graft uptake and longer hospital stays compared to male patients. Conclusion: Carica papaya pulp dressings significantly improve the healing of diabetic ulcers, promoting faster granulation, better graft uptake, and shorter treatment periods. This study supports the use of papaya pulp as an effective, low-cost alternative for diabetic ulcer management, particularly in resource-limited settings. Further studies are warranted to refine treatment protocols and explore its broader clinical applications.